Detalhe da pesquisa
1.
Evidence That Sedative Effects of Benzodiazepines Involve Unexpected GABAA Receptor Subtypes: Quantitative Observation Studies in Rhesus Monkeys.
J Pharmacol Exp Ther
; 366(1): 145-157, 2018 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29720564
2.
Inhibition of TRPM8 channels reduces pain in the cold pressor test in humans.
J Pharmacol Exp Ther
; 351(2): 259-69, 2014 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-25125580
3.
Drugging DNA Damage Repair Pathways for Trinucleotide Repeat Expansion Diseases.
J Huntingtons Dis
; 10(1): 203-220, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-32925081
4.
A short perspective on the long road to effective treatments for Alzheimer's disease.
Br J Pharmacol
; 176(18): 3636-3648, 2019 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30657599
5.
Photosensitive epilepsy: Robust clinical efficacy of a selective GABA potentiator.
Neurology
; 92(15): e1786-e1795, 2019 04 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30877186
6.
Design and Identification of a Novel, Functionally Subtype Selective GABAA Positive Allosteric Modulator (PF-06372865).
J Med Chem
; 62(12): 5773-5796, 2019 06 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-30964988
7.
Potentiation of reflex erectile responses in the anaesthetized rat by the selective melanocortin receptor 4 agonist MB243.
BJU Int
; 102(8): 1029-33, 2008 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-18494830
8.
The value of genetic and pharmacological approaches to understanding the complexities of GABA(A) receptor subtype functions: the anxiolytic effects of benzodiazepines.
Pharmacol Biochem Behav
; 90(1): 37-42, 2008 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-18457867
9.
A randomised, placebo-controlled clinical trial with the α2/3/5 subunit selective GABAA positive allosteric modulator PF-06372865 in patients with chronic low back pain.
Pain
; 159(9): 1742-1751, 2018 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-29787472
10.
Pharmacology in translation: the preclinical and early clinical profile of the novel α2/3 functionally selective GABAA receptor positive allosteric modulator PF-06372865.
Br J Pharmacol
; 175(4): 708-725, 2018 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29214652
11.
Designing drugs for the treatment of female sexual dysfunction.
Drug Discov Today
; 12(17-18): 757-66, 2007 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-17826689
12.
Differential contribution of GABA(A) receptor subtypes to the anticonvulsant efficacy of benzodiazepine site ligands.
J Psychopharmacol
; 21(4): 384-91, 2007 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-17092983
13.
Evidence for a significant role of alpha 3-containing GABAA receptors in mediating the anxiolytic effects of benzodiazepines.
J Neurosci
; 25(46): 10682-8, 2005 Nov 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-16291941
14.
The in vivo properties of pagoclone in rat are most likely mediated by 5'-hydroxy pagoclone.
Neuropharmacology
; 50(6): 677-89, 2006 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-16430927
15.
A pyridazine series of alpha2/alpha3 subtype selective GABA A agonists for the treatment of anxiety.
J Med Chem
; 49(8): 2600-10, 2006 Apr 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-16610803
16.
Discovery of imidazo[1,2-b][1,2,4]triazines as GABA(A) alpha2/3 subtype selective agonists for the treatment of anxiety.
J Med Chem
; 49(4): 1235-8, 2006 Feb 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-16480260
17.
Genetic mapping of variation in spatial learning in the mouse.
J Neurosci
; 23(6): 2426-33, 2003 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-12657702
18.
Sedation and anesthesia mediated by distinct GABA(A) receptor isoforms.
J Neurosci
; 23(24): 8608-17, 2003 Sep 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-13679430
19.
STOP knockout and NMDA NR1 hypomorphic mice exhibit deficits in sensorimotor gating.
Behav Brain Res
; 163(2): 257-64, 2005 Sep 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-16046005
20.
The mouse beam walking assay offers improved sensitivity over the mouse rotarod in determining motor coordination deficits induced by benzodiazepines.
J Psychopharmacol
; 19(3): 221-7, 2005 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-15888506